Hence the school was established with Rev. Sr. Mary Bertha as the principal and three other sisters. The school was named after the great grandmother of Jesus Christ, St. Anne.

In 1924 Rev. Sr. Mary Bertha was transferred and Miss Elaine Lorage took over the charge of the school and became the first layperson to become the Principal of the school.

In 1931 a new era begins with Rev. Sr. Mary Felicitas as the new principal.

Rev. Sr. Mary Angel became the principal and the school which was formally established as an English medium school initiated to educate the students in Sinhala medium as well. The lessons were conducted in both mediums English medium in the morning and Sinhala medium in the evening.

In 1940 Rev. Sr. Mary Angels was transferred and Rev. Sr. Mary Adrienne assumed duties as the new principal.

In 1949 Rev. Sr. Mary Good Shepherd became the principal and in the same year the houses were reformed and established as Andrew, Anthony, Chantal and Pascal and recognized the different accomplishments of the students. .

Rev. Sr. Mary Good Shepherd retired and Rev. Sr. Mary Eugene became the principal . This was the year the school initiated the studies in Commerce stream. The Advanced Level studies in Arts steam was also commenced in this year. The buildings for this purpose were constructed along with a home science room and a science laboratory.

In 1973 Rev. Sr. Mary of the Angels became the principal.

Mrs. M. L. J. Ferdinandes became the principal of the school and she was the second layperson to become the principal of St. Anne’s. Construction of a new three storey building for the secondary school and a two storey building for the primary section was began in this year.

In 1999 Mrs. M. L. J. Ferdinandes who had been the principal of the school for a long tenure retired from her post and Rev. Sr. Mary Rita Fernando assumed duties as the Principal.

The year 2004 marked the beginning of another golden era of the history of the school and the school which was led by the Good Shepherd sisters was passed over to a sister of Dominican congregation. The present principal Rev. Sr. Kanthi Perera took over the leadership of the school. With the administration of the present principal a significant changes have been taken place. The completion of the construction of the new three storey building which was being done then and naming it as St. Rose of Lima, the renovation of the home science building, Science Laboratory and the library were done under her guidance.